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Saturday, August 1, 2020 | History

4 edition of Mechanisms of cytotoxicity by NK cells found in the catalog.

Mechanisms of cytotoxicity by NK cells

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  • 19 Currently reading

Published by Academic Press in Orlando .
Written in English

    Subjects:
  • Killer cells -- Congresses.,
  • Cell-mediated cytotoxicity -- Congresses.,
  • Cytotoxicity, Immunologic -- congresses.,
  • Immunity, Cellular -- congresses.,
  • Killer Cells, Natural -- immunology -- congresses.

  • Edition Notes

    Other titlesMechanisms of cytotoxicity by natural killer cells.
    Statementedited by Ronald B. Herberman, Denis M. Callewaert.
    ContributionsHerberman, Ronald B., 1940-, Callewaert, Denis M., International Workshop on NK Cells (3rd : 1984 : Oakland University)
    Classifications
    LC ClassificationsQR185.8.K54 M43 1985
    The Physical Object
    Paginationxxiii, 669 p. :
    Number of Pages669
    ID Numbers
    Open LibraryOL2557122M
    ISBN 100123413702
    LC Control Number85070441

    CDtransfected P cells were killed by NK cell lines expressing CD40L, clones and PBL-derived NK cells cultured for 18 h in the presence of IL . Fluoride (F) is ubiquitous natural substance and widespread industrial pollutant. Although low fluoride concentrations are beneficial for normal tooth and bone development, acute or chronic exposure to high fluoride doses results in adverse health effects. The molecular mechanisms underlying fluoride toxicity are different by nature. Fluoride is able to stimulate G-proteins with Cited by:

      Antibody-dependent cellular cytotoxicity (ADCC) has recently been identified as one of the critical mechanisms underlying the clinical efficacy of therapeutic antibodies, especially anticancer antibodies. Therapeutic antibodies fully lacking the core fucose of the Fc oligosaccharides have been found to exhibit much higher ADCC in humans than their Cited by: Cutting edge and thorough, Natural Killer Cells: Methods and Protocols is a valuable resource for researchers who not only want to understand mechanisms that govern NK cell behavior and diversity, but also for those who want to understand how to systematically evaluate NK cells for adoptive immunotherapy : Hardcover.

    Natural killer cells, also known as NK cells or large granular lymphocytes (LGL), are a type of cytotoxic lymphocyte critical to the innate immune role of NK cells is analogous to that of cytotoxic T cells in the vertebrate adaptive immune cells provide rapid responses to virus-infected cells, acting at around 3 days after infection, and respond to tumor formation.   Usually NK cells do not survive for a long period of time without cytokine support. 21 Therefore, to understand the mechanisms of γδ T lymphocyte–mediated NK-cell activation in a more physiologic model, in this study we used a short-term culture of fresh NK cells purified from PBMCs of healthy donors and γδ T lymphocytes expanded in by:


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Mechanisms of cytotoxicity by NK cells Download PDF EPUB FB2

Mechanisms of Cytotoxicity by NK Cells is the resulting book of a workshop focused on the studies that enhance understanding of the basic mechanisms involved in the function and regulation of NK cells. The book presents the status of knowledge of the mechanisms responsible for the cytotoxic effects of NK cells and the regulation of their activity.

Mechanisms of Cytotoxicity by NK Cells is the resulting book of a workshop focused on the studies that enhance understanding of the basic mechanisms involved in the function and regulation of NK cells.

The book presents the status of knowledge of the mechanisms responsible for the cytotoxic effects of NK cells and the regulation of their Edition: 1.

Mechanisms of Cytotoxicity by NK Cells is the resulting book of a workshop focused on the studies that enhance understanding of the basic mechanisms involved in the function and regulation of NK cells. The book presents the status of knowledge of the mechanisms responsible for the cytotoxic effects of NK cells and the regulation of their by: Mechanisms of cytotoxicity by NK cells.

Orlando: Academic Press, (OCoLC) Online version: Mechanisms of cytotoxicity by NK cells. Orlando: Academic Press, (OCoLC) Material Type: Conference publication: Document Type: Book: All Authors / Contributors: Ronald B Herberman; Denis M Callewaert.

The symposium provided a forum for reviewing the progress that has been made in understanding the effector and regulatory mechanisms underlying natural and induced cell-mediated cytotoxicity.

Topics covered range from the immunobiology of natural killer cells to the role of macrophages as regulator, accessory, and effector cells in cytotoxicity.

COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle.

NK cells kill target cells by either of two major mechanisms that require direct contact between NK cells and target cells.

In the first pathway, cytoplasmic granule toxins, predominantly a membrane-disrupting protein known as perforin, and a family of structurally related serine proteases (granzymes) with various substrate specificities, are Cited by: MECHANISMS OF CYTOTOXICITY: MOLECULES AND PHENOMENA ASSOCIATED WITH EFFECTOR CELLS AND TARGET CELLS.

Characterization of a Sulfatase From Granules of Natural Killer (NK) Cells (Andrew A. Amoscoto, Anne M. Brumfield, Stephanie B. Sansoni, Ronald B. Herberman, and WIlliam H. Chambers). Natural killer cell cytotoxic activity NK cells also initiate target cell apoptosis through the death receptor pathway [24].

Tumour necrosis factor (TNF) ligands expressed on NK cells bind to the Fas (CD95/Apo-1) and TNF-related apoptosis inducing ligand (TRAIL) on the target cell to induce apoptosis [29, 32]. Natural killer (NK) cells are part of the innate arm of the immune system.

Their function is to eliminate aberrant cells, including virally infected and tumorigenic cells. For this purpose NK cells store cytotoxic proteins within secretory lysosomes, specialized exocytic organelles that are also known as lytic by: Cytotoxicity is the general quality of being toxic to cells, and can be caused by chemical stimuli, exposure to other cells (NK or T cells for example), or physical/environmental conditions (radiation exposure, temperature or pressure extremes, etc.).Author: Tülay Aşkin Çelik.

The First International Workshop on Mechanisms in Cell-Mediated Cytoxicity was held at Carry-Ie-Rouet, France, SeptemberThe Workshop brought together for the first time leading investiga­ tors in each of the principal areas of cell-mediated cytotoxicity, as well as experts in the area of complement-mediated cytoxicity.

NK cells express high levels of CD16, while CD56bright NK cells are CD16 dim or negative16 (Figure 1). Adoptive Transfer of NK Cells to Target Tumors Their rapid killing and broad cytotoxicity make NK cells uniquely primed for use in adoptive therapy.

In vitro, NK cells exert Figure 1. Mechanisms of NK-Mediated Cytotoxicity (A) Spontaneous File Size: KB. NK cells play an important role in host immunity against cancer by exerting cytotoxicity and secreting a wide variety of cytokines to inhibit tumour progression.

Their effector functions are regulated by the integration of opposing signals from activating and inhibitory receptors, which determine NK cell activity against tumour targets.

NK cell cytotoxicity requires successful Author: May Sabry, Mark W. Lowdell. Specific topics discussed include NK cell receptors and adhesion molecules, signal transduction and activation, and mechanisms of cytotoxicity.

The book will be an excellent learning tool and reference resource for scientists, clinicians, and students. Mechanisms of Cytotoxicity. The granules of NK cells contain proteins such as perforin and proteases known as granzymes. Upon binding to a cell slated for killing, perforin forms pores in the cell membrane of the target cell, creating an aqueous channel through which the granzymes and associated molecules can enter, inducing either apoptosis or osmotic cell lysis (a form of.

Herberman R.B. () Overview on NK Cells and Possible Mechanisms for their Cytotoxic Activity. In: Clark W.R., Golstein P. (eds) Mechanisms of Cell-Mediated Cytotoxicity. Advances in Experimental Medicine and Biology, vol Cited by: 9. the mechanisms of toxicity likely to be observed during in vivo studies.

To assess the effects of test compounds on cell viability, cell proliferation and macromolecule synthesis, ImQuest’s cytotoxicity evaluations are per-formed with a number of human immune system cell types and cell types representative of the major functional organ Size: KB. Mechanism of Cytotoxicity by Natural Killer (NK) Cells.

Annual Review of Immunology Vol. (Volume publication date April ) Annual Review of Immunology NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines Tumor escape mechanisms.

The immune system exerts selective pressure on tumors through Cited by: CTLs and NK cells are important effector cells in the immune responses to virus-infected cells and neoplastically transformed cells [][][]14,[][] [].

Both types of cells kill. This book is derived from contributions to the Second International Workshop on Mechanisms in Cell-Mediated Cytotoxicity, held in Annopolis, Maryland, JuneThis workshop was organized by an international committee of immunologists interested in lymphocyte cytotoxic mechanisms (G.Antibody-dependent cellular cytotoxicity (ADCC), also referred to as antibody-dependent cell-mediated cytotoxicity, is a mechanism of cell-mediated immune defense whereby an effector cell of the immune system actively lyses a target cell, whose membrane-surface antigens have been bound by specific antibodies.

It is one of the mechanisms through which antibodies, as part of .Measuring NK Cell cytotoxicity: LAMP1/CDa assay • Measures release of cytotoxic granules. • The membrane of cytotoxic granules contains specific proteins e.g. LAMP1 transiently expressed on the surface of NK Cells which can be detected by flow cytometryFile Size: 2MB.